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A5.7: Light Activable Nanoparticles and Biomolecules as Structural Basis for Design of Functional Photonic Nanodevices and Switchable Cell Probes

Subproject Leader: Ljiljana Fruk

Young Scientist Group - Fruk, KIT

 

Contributing Scientists:

Present: Ishtiaq Ahmed, Bianca Geiseler, Dania Kendziora, Lukas Stolzer
Past: Andre Petershans, Martina Altemöller, Fritz Daniel

 

Protein-DNA Conjugate
Fig.1: Protein-DNA Conjugate
Protein-Quantum Dots Hybrids
Fig. 2: Protein-Quantum Dots Hybrids
Catechol Based Linkers for Nanoparticle modification
Fig. 3: Catechol Based Linkers for Nanoparticle Modification

The aims of this interdisciplinary project is to harvest the potential of different classes of nanoparticles for design of biosensors, cell delivery systems and the study of signalling pathways within the cell. In addition, the nanostructuring potential of different classes of biomolecules such as DNA and peptides, which can be used both in the development of new bio based materials and catalysts, is investigated.

Four different sub projects are established to tackle different aspects of the project:

  1. DNA and Peptide Modifications for Protein Conjugation and Immobilisation (Fig. 1)

  2. Design of Protein/Peptide Nanoparticle Hybrids (Fig. 2):
    a) by use of chemical modifications and bio friendly linker systems1
    b) in vivo formation of metal nanoparticles

  3. Synthesis of Trifunctional Linkers for Nanoparticle Modification

  4. Synthesis, Modifications and Characterisation of Nanoprobes2 (Fig. 3)

References

[1] A. Petershans, D. Wedlich, Lj. Fruk, Chem Commun 2011, 47, 10671
[2] B. Geiseler, Lj. Fruk, J. Mater. Chem. 2012, 10.1039/C1JM12863A, in press


List of Publications 2006-2011 as PDF

Subproject Report 2006-2010 as PDF